The 12th National Conference and the 3rd International Bioinformatics Conference, اسفند ماه ۱۴۰۲

Accepted papers in The 12th National Conference and the 3rd International Bioinformatics Conference

• Identification of Novel miRNAs Encoded by MSI۱ Gene Using Bioinformatic andExperimental Methods

• Molecular docking simulation of Anticancer properties of Cisplatin as an ovarian cancer inhibitor

• Enhancing Heart Failure Prediction Accuracy through Effective Preprocessing andPrincipal Component Analysis

• Molecular docking simulation of Antibacterial properties of Teixobactin as Bacillus anthracis inhibitor

• Distribution of Estrogen Receptor ۱ (ESR۱) gene (rs۲۲۳۴۶۹۳) polymorphism among breast cancer patients from Mazandaran province, Iran; a case-control study

• FN۱, COMP, and CXCL۵, serve as diagnostic biomarkers for pancreatic cancer, as revealed through analysis of microarray data

• Pathogenicity prediction of a missense mutation (p.Pro۲۵۰Arg) in the FGFR۳ gene associated with achondroplasia

• Identification and Analysis of Crucial Genes Underlying Gastric Cancer via Bioinformatics Techniques

• Prediction of Pathogenicity of rs۱۲۵۲۶۹۲۷۳۲ p.Gly۱۵۱Val missense mutation (rs۱۲۵۲۶۹۲۷۳۲) in MTTP Gene Associated with Abetalipoproteinemia by BioinformaticsTools

• A Bioinformatics study: predicting the pathogenicity of two SNPs in the CFTR gene which is associated with Cystic Fibrosis (CF) disease

• Identification of hub genes as novel biomarkers in Ovarian Cancer using High-Throughput Transcriptome data analysis

• Computational Modeling and Machine Learning Evaluation of Factors Impacting Regional Nasal Dosage Delivery for Micro-Sized Peptide-Based Therapeutics

• Revolutionizing NSCLC Treatment: Exploring the Potential of In Silico-designed Multiepitope Vaccines

• Pathogenicity prediction of a single nucleotide polymorphism (rs۱۰۴۸۹۴۱۰۷: p.G۱۳۰V) in human FXN gene

• lactate dehydrogenase A inhibition via peptides to regulate the Warburg effect: cell signaling analysis

• Using the recommended protein marker gpd to investigate the phylogeny relationships among ۲۳ species of bioindicator fungal genus Lactarius

• Molecular Modeling of Monomeric Spike SARS-CoV-۲ - Ferritin Nanoparticle Vaccine

• Transfer Learning Based on DenseNet-۱۲۱ Model: A Deep Learning Approach to Promote Detecting Breast Cancer in Thermogram

• Semantic Segmentation Based on Artificial Intelligence: An Effective Paradigm for Automated Estimation of Fetal Head Circumference in Ultrasound Images

• Bioinformatics approach for shedding light on controversial information of IGF۱/۲ expression pattern in hepatocellular carcinoma

• From Melanoma to Skin Aging: The Impact of DCT and TYRP۱ in Melanogenesis

• Expression data from human breast tumors and their paired normal tissues proteinprotein interaction

• An in-silico study on some synthesized triazole derivatives as tyrosinase inhibitors

• Identification of biomarkers for breast cancer in different reproductive ages using computational methods

• c.۵۲۴۴ del G: A Novel Mutation in the ABCA۴ Gene is Associated with Retinitis Pigmentosa

• Molecular profiling of downregulated genes in T-DM۱ resistance: insights from OE-۱۹ esophageal cancer cells

• Re-purposing Clove Oil in Ovarian Cancer Treatment: A Multi-Dimensional Approach Involving Bulk RNA-Seq and scRNA-SeqDescription

• Prediction of pathogenicity of rs۱۸۰۰۷۵۱ (Pro۱۸۱۲Thr) nucleotide change in BRCA۱ gene related to breast cancer by bioinformatics tools

• Solubility, mathematical modeling and thermodynamic properties of budesonide solubility in ۱-Propanol+Water from T = (۲۹۳.۲ to ۳۱۳.۲) K

• In silico discovery of small-molecule K-Ras inhibitor

• A whole genome sequencing approach for unraveling the genetic basis of antibiotic resistance in Iranian Helicobacter pylori isolates

• Stabilization of Aspergillus flavus urate oxidase enzyme by site-directed mutagenesis

• Evaluation of neural network for computing accuracy of genomic breeding value

• A Hybrid Deep Learning-based Model for Off-target Prediction in CRISPR System

• Computational Designing of Chimeric Antigen Receptor Extracellular Regions: Homology modelling, Docking and Molecular Dynamic Simulations

• Binary Gravitational Search Algorithm Feature Selection method for DTI

• Omics Technologies and Data mining approaches in Canine Osteosarcoma: Insights from High-Throughput Genetics and Bioinformatic Analysis

• Analyzing Monomeric and Dimeric ORF۸ Interactions with Antiviral Small Molecules

• Identification of specific gene modules related to the Meyloid Blast Crisis (MBC) phase of CML Using MAGI Algorithm

• Efficient classification of single cell ATAC sequence data using machine learning

• Unraveling Therapeutic Prospects for Endometriosis: Modulating AKT۱ with an Established Breast Cancer Drug, Capivasertib

• The role of imatinib on the differentiation genes expression in K۵۶۲ cell line: A bioinformatic study

• Computational vaccine designing against Nipah virus G and F proteins using structural modeling and dynamic simulations

• Evaluation of ۵-fluorouracil related genes in breast cancer involved in the microtubule structure

• Mathematical modeling for azole drugs solubility in the binary solvent systems at various temperatures

• Analysis of Co-Expression Network of BMPR۱B Gene with Other Genes Involved in litter Size of Sheep

• Association of IL۱۸ and CSF۱R overexpression leads to immunosuppressive phenotypes in microglial cells in GBM microenvironment: A transcriptome-wide meta-analysis

• Integration of genomic data and machine learning to identify signature genes in pyroptotic cell death in neural cells of AD patients

• Celastrol strongly binds to AMPK activating site: A docking study

• Understanding the Activity of BMPR۱B within the BMP/SMAD Pathway in Sheep

• Deciphering transcriptomic signatures in myotonic dystrophy: a bioinformatics casecontrol study

• The impact of adding a functional group to the antimalarial drug Artemisinin on its penetration into biological membranes using molecular dynamics simulation

• Comparison of the toxicity of Doxorubicin in water and natural deep eutectic solvents based on choline chloride by molecular dynamics simulation

• Drug design for the treatment of autoimmune diseases by Increasing the binding affinity of IL-۲۱R Protein to IL-۲۱

• Predicting the pathogenicity of a missense mutation (Glu۸۸Lys) in the NCAPG gene involved in childhood hepatocellular carcinoma using bioinformatics tools

• Bioinformatics Analysis of Microarray Data to Identify Hub Genes as Novel Biomarkers for Colorectal Cancer

• Identification of potential inhibitors of kidney glutaminase using molecular docking simulations

• In-silico Comparison of Interaction Some Bee Venom Peptides with the Mouse mMHCMOG: ۳۷-۴۶ complex as a Potential Treatment of MS Disease

• Unraveling Protein Dynamics in the Presence of Cellulose Nanocrystals: An Essential ۱Dynamics Analysis

• Designing mutated protein with increased binding affinity to Il-۲۲ in

• Prediction of Pathogenicity of a Single Nucleotide Polymorphism (rs۲۱۳۳۷۸۵۶۹۳) in human CDKN۱C gene Associated with Wilms Tumor

• In Silico Design of a Novel Antibody-Drug Conjugate Targeting Mesothelin in Pancreatic Cancer

• Morbillivirus Cellular Receptor Interaction: Introduce Potential Important RegionsInvolved in Novel Cellular Receptor

• Multi-Omics Integration for Pancreatic Adenocarcinomas Subtyping

• Predicting Functional miRNA Targets in C-Fos with High Accuracy via Machine Learning

• Deciphering the c-MYC miRNA Regulatory Network through Machine Learning

• Drug repositioning and the candidates' mechanism of action for vitiligo

• Investigation of the internal co-expression relationship evolution in chronic rhinosinusitis with nasal polyps

• Unlocking Drug Combinations: A Novel Graph-Based Approach for Predicting Anti-Cancer Synergy

• Functional investigation of MYL۹ gene in signaling pathways and gene networks in chicken

• Comprehensive discovery of markers effective in disease severity in the genome of Iranian patients with covid-۱۹

• TWIST۱ and Stomach Adenocarcinoma: Deciphering the Molecular Landscape of Metastasis-Related Genes

• In silico analysis of identification dysregulated genes in doxorubicin treatment human cervical cancer cell (HeLa)

• Targeting the Tumor Stroma: Identifying Crucial Genes in Cancer-Associated Fibroblasts for High-Grade Serous Ovarian Cancer Therapeutics

• Identification of crucial genes and pathways associated with Hepatocellular carcinoma based on bioinformatics analysis

• Deciphering Tumor Microenvironment Dynamics and Cellular Communication in Breast Cancer Progression through Single-Cell RNA Sequencing

• Advancing Feature Selection: A Hybrid Approach for High-Dimensional and Incomplete Data

• Ensemble based variational autoencoders for detecting protein complexes in proteinprotein interaction networks

• Transcriptomics analysis of lung samples of COPD patients identifies shared pathways involved in the disease among independent studies

• Transcriptomic Data Mining to Identify Circular RNAs as Biomarkers in the Development of Grape Clusters

• High-throughput transcriptome analysis for identification of Helicobacter pylori vaccine target antigens

• Logical engineering of cellulase enzyme isolated from Acidothermus cellulolyticus bacteria for increasing thermal stability

• Deciphering the Regulatory Symphony: MicroRNA Orchestration of the RAS/MAPK Signaling Pathway and its Interplay across Cellular Networks in Colorectal Cancer Tumorigenesis – A Systems Biology Perspective

• The promotor methylation level of ATG۱۲ correlates with tumor progression and autophagy in Bladder cancer; A bioinformatic study

• Assessment of the isolated compounds from Cumin (Cuminum cyminum) as inhibitor of VEGFR-۲ using molecular docking methodology

• Medical Image Segmentation using EfficientNet-based U-Net Architecture

• In-silico analysis of a missense mutation (Leu۳۰۹Pro) in the PYGM gene associated with Glycogen storage disease type V

• The Expression Level of SQSTM۱ Related to the Progression and Autophagy of Gastric Cancer Based on TCGA

• In silico analysis of single nucleotide polymorphisms (SNPs) in human HGD gene which is associated with Alkaptonuria

• Bioinformatic Discovery of Novel FGFR-۱ Inhibitors from Natural Products: A Promising Approach for Lung Cancer Treatment

• Analysis and Prediction Hormonal Effects of Metformin on PCOS in Mice using Machine Learning algorithms

• In silico identification of G-quadruplex structure in the STAT-۶ gene sequence

• Analysis and Prediction PCOS Using Classification Algorithms

• Presbycusis: Ranking the genes and associated biological function

• Isolation and computational investigation of class ۳ L- asparaginase form a native Glutamicibacter. SP.

• An Innovative Unbalanced ANOVA-Based Approach for Multi-Dimensional Feature Evaluation in Brain-Computer Interface Classification

• In silico evidence for the efficacy of egg peptides in type ۲ diabetes treatment

• Berberine and Liver Cancer: Analyzing Gene Expression for Therapeutic Clues

• A Computational Prediction of Novel PET-Degrading Enzymes: Pathway to Sustainable Plastic Management

• Identification of key differentially expressed miRNAs and their potential target genes in Non-small cell lung cancer using bioinformatics analysis

• Missense HRC- rs۳۷۴۵۲۹۷ Gene Polymorphisms May Correlate to Humans Cardiac Arrhythmia: A In silico Study

• Transcriptomics-Based Computational Drug Repurposing Strategy For Identified Therapeutic Candidates Tuberculosis meningitis

• A Multi-Modal Deep Learning Framework for Prostate Cancer Detection Using MRI

• In-silico Strategy for the Affinity Improvement of the Anti-TNF-α Antibody Drug by Site-Directed Mutagenesis Approach

• Unraveling Key Pathways and Hub Genes in Oral Cancer: An Integrated Bioinformatics Analysis

• Simulation of the Ossicular Chain of the Middle Ear for Material Assignment Purpose

• Bioinformatic Analysis of P۵۳ Mutations in Cancer

• Investigating the Association between NID۱ Gene SNPs with Mandibular Prognathism: An In silico Study

• Tracing the controller genes related to the metastasis mechanisms in squamous cell carcinoma of the head and neck

• Investigating the Association between SNPs in AGT Gene with Preeclampsia: A In silico Study

• Hub gene identification and correlation with tumor-infiltrating immune cells in esophageal carcinoma; an RNA-seq and protein-protein interaction analysis

• Down-regulation of the DAPK۳ gene is associated with the metastasis of papillary thyroid tumors to the lungs

• Artificial Intelligence-based Classification of Glioblastoma Lifespan: Unveiling the Role of TMEM۱۷۶A

• Investigating the Inhibitory Effect of Curcumin on FGFR۴: Insights from Docking Studies

• Deep Learning Framework for Splice Site Prediction Across Multiple Species

• Bioinformatics Analysis of flavanone-۳՛-hydroxylase (F۳՜H) in Silybum marianum

• Design of a Novel Ligand Derived from Nigella_Sativa Plant to Inhibit Voltage-Dependent Calcium Channel to Diminish Blood Pressure Using Bioinformatics Tools

• Identification of Key Genes and Shared Metabolic Pathways in Multiple Sclerosis and Bipolar Disorder Using Systems Biology Approaches

• The Potential Therapeutic Effects of Quercetin in Type ۱ Diabetes: Targeting Essential Genes and Pathways

• A Bioinformatic study of the chalcone synthase (CHS۳) gene among different species

• Homology Modeling and Molecular Dynamics Simulation of Recombinant Laccase

• Designing targeted PROTAC-based therapeutics against mutant p۵۳ proteins through structure-based virtual screening and dynamic simulations

• CDC۲۷ pseudogene expression in blast crisis phase of CML

• Splicing Detection In DNA Sequences With A Focus On Balancing Visual Data And Deep Neural Networks

• Deciphering the Role of CircRNA-miRNA Networks in Multiple Sclerosis Pathogenesis through Minimal Cut-Set Analysis

• Study of Lactobacillus Strain L۲۸ Using Bioinformatics Methods

• Exploring the Synergistic Anticancer Effects of Iranian Medicinal Plants on EGFR Driven Tumor Cell Lines: Integrative Computational and Molecular Dynamics Study)

• Enrichment analysis of potential hub genes in breast cancer based on TCGA datasets

• Computational Discovery of Antimicrobial Enzymes from Environmental Microbiota

• Alzheimer's Disease Detection Using MRI Analysis with Recurrent Deep Networks

• Comparative genomics of ۹۱۹ microbial genomes of the order Oceanospirillales for oil hydrocarbon degradation

• Exploring Epigenetic Methylation Patterns in Parkinson's Disease through WGCNA Analysis

• Enhancing Predictive Accuracy of Biomolecules Partition Coefficients in Aqueous Two-Phase Systems Using Machine Learning

• Ecotoxicological classification risk index for soil (ECRIS) prediction of some phenolic compounds using multiple linear regressions and artificial neural network QSPR paradigm

• Integrative Bioinformatics Analysis of Breast Cancer-Derived Extracellular Vesicles in Mediating Cancer-Associated Fibroblast Activation

• Integrative Bioinformatic analysis of differentially expressed genes and miRNA regulation in neoadjuvant chemotherapy resistance in HER۲+ breast cancer

• Down-regulation of the LAMB۳ gene induces pulmonary metastasis in thyroid cancer

• Exploring Traditional Machine Learning and Deep Learning for Predicting Intracytoplasmic Sperm Injection (ICSI) Success Rates

• Solving haplotype assembly problem by applying particle swarm optimization

• Microscopic Classification of Microbial Species Using Deep Learning

• Molecular reasons for the effectiveness of Zinc in modulating Psoriasis

• Performance evaluation of flexible-receptor docking tools based on the peptide length

• Quantitative EEG Features to Diagnose Anxiety Disorders

• Elucidating the Impact of Opium Consumption on Blood Parameters Using Network Analysis and Machine Learning

• Investigation of FLS۱ Enzyme Involved in the Flavonoids Biosynthesis in Carthamus tinctorius Using Bioinformatics Techniques

• A Novel Mechanistic Simulation Model for Single-Cell DNA Sequencing

• A platform for de novo peptide sequence library generation

• Identification of Genes and Pathways Associated with Depression in Ovarian Cancer Patients: An In-silico Study

• Investigating the Molecular Docking of Herbal Compounds Quercetin, Isorhamnetin, and Thymoquinone Against Human Epidermal Growth Factor Receptor ۲

• Transcriptomics-Based Computational Drug Repurposing Strategy Identifies Therapeutic Candidates for Parkinson's Disease

• Differentiation of glioblastoma multiforme solid and recurrent tumors using gene expression profile and machine learning algorithms

• Identifying key miRNAs and mRNAs involved in EMT in papillary thyroid carcinoma using bioinformatics techniques

• Whole Exome Sequencing of a Family with Non-obstructive Azoospermia Men did not Show the C۶۷۷T Variant as an Infertility Risk Factor

• Screening of cyanobacterial bioactive peptides against viral infections

• A Deep Learning Approach for Peptide-based Treatment Design

• Predicting the impact of missense mutations on the protein structure networks: a case study on human phenylalanine hydroxylase and α-galactosidase

• Discovering the Secrets of Gastric Cancer: Key Genes and Interaction Networks Revealed Through Bioinformatics

• Colon Cancer Detection on Imbalanced Dataset based on using SMOTE

• Cancer Prediction through Advanced Gene Expression Analysis Using Machine Learning Method

• S-Adenosylhomocysteine hydrolase: an evolutionary analysis on the structure and sequence

• A method to visualize pseudo-potential landscape of high-dimensional Boolean networks

• Pathogenicity Prediction Assays of Human Missense Variant (rs۱۴۸۴۹۵۴۴۵۰) in CTLA-۴ Gene Based on Protein Sequence, Structure and Function

• Reveal Genetic Links Among COVID-۱۹, A Deep Neural Network Method to Alzheimer's Disease, and Multiple Sclerosis Based on Single-Cell RNA-seq

• Breast cancer early detection biomarkers identified from ductal carcinoma in-situ patients: a bioinformatics approach

• Efficient Hybrid algorithm for Gene Selection Based on Chaos Game Optimization

• Enhancing Drug Design for VEGFR۲: Integrating Quantum Mechanics-Driven ۳D QSAR with Deep Learning to Predict Drug Efficacy

• A Siamese neural network for immunotherapy response prediction

• Transcriptomics-Based Systems Biology Analysis Suggests New Potential Biomarkers for Colorectal Cancer

• Enrichment analysis of potential hub genes in Acute Myeloid Leukemia based on TCGA datasets

• Rs۳۵۱۰۷۹۶۲ modifies Microtubule Cytoskeleton Organization via Frameshift in MAP۷ Gene and Protein in Skin Cancer patients: in-silico investigation

• AKR۱B۱۰ overexpression correlating with LINC۰۱۳۵۹ and hsa-miR-۴۴۸۲-۳p predicts worse overall survival in hepatocellular carcinoma

• Assessment of the RBP۴ gene and LncRNA LINCO۱۲۱۵ in individuals with breast cancer

• G-quadruplex structures in ring finger protein ۱ (RING۱) gene sequence

• HSA-MIR-۵۳۹-۵P promots gastric adenocarcinoma by disturbing interactions of STK۳۲A-AS۱ as a lncRNA

• Gastric cancer (GC) represents the fifth most common tumor and the fourth leading cause of cancer-related deaths worldwide[۱]. Several genetic and epigenetic factors, including microRNAs(miRNAs) and lncRNAs, affect its initiation and progression. MiRNAs are short chains of nucleic acidsthat can regulate several cellular processes by controlling their gene expression, Long noncodingRNA (LncRNA) is a large class of RNA molecules with size larger than ۲۰۰ nucleotides. They exhibitcellular functions although having no protein-coding capability [۲]. In recent decades, miRNAa andlncRNAs have been st

• Investigating DCAF۱۰ Gene Expression and its Correlation with Azoospermia

• Re-purposing Clove Oil in Ovarian Cancer Treatment: A Multi-Dimensional Approach Involving Bulk RNA-Seq and scRNA-Seq

• A subspace learning aided matrix factorization for drug repurposing

• Identification of biomarkers involved in the development of grade II meningiomas using the systems biology approach

• Structural and Functional Consequences of a Novel DDX۳X Frameshift Mutation: A Computational Perspective

• scFedVI: A Privacy-Preserving Approach to Mitigating Batch Effects in Single-Cell RNA-Sequencing Data

• Zika virus vaccine design based on epitopes

• Deep Convolutional Neural Network Model for Predicting MHC I Binding Affinity in Peptide-Based Therapeutics

• Reconstruction of the miRNA-mRNA regulatory network specifically in the remission and relapse phase of people with multiple sclerosis

• New feature selection method based on random forest for cancer classification

• IDENTIFICATION OF CANDIDATE TREATMENT TARGETS IN ESOPHAGEAL CANCER: A COMPREHENSIVE BIOINFORMATIC ANALYSIS

• Identification of potential prognostic biomarkers in lung adenocarcinoma: A networkbased approach

• Inference of gene regulatory network using dimension reduction methods and rotation forest

• Study of the Effect of Cinnamon Plant Hydrosol (Cinnamomum verum) on Peroxidase and Lipase

• Improved the performance of pathway topology-based methods using Perti Net

• In-Silico Pathogenicity Prediction of a Human Missense Variant (rs۱۴۷۳۹۶۲۶۳) of NANOS۲ Gene In the Patients with Varicocele Disease

• Applying various strategies in machine learning models to predict Type II diabetes by using the risk factors

• DeepSiPPI: Enhancing Protein-Protein Interaction Prediction through Siamese Neural Networks and Sequence-to-Image Transformation

• Enhancing Precision for Background Mutation Rate Estimation in Cancer Genomes

• Enhancing Model Evaluation in Single-Cell Perturbation Response Prediction

• Cancer Gene Expression Classification Using Machine Learning Methods

• Translation Initiation Site Prediction based on the TITER and Machine Learning Method

• AI-powered PET imaging analysis for enhanced Parkinson’s disease diagnosis

• Identification and Evaluation of Neoantigens in Melanoma Patients Using Data Fusion

• Computational Modeling for Predicting and Designing Melanoma Neoantigens

• Theoretical modelling of surface plasmon resonance biosensor employing graphene and SnSe heterostructure for Pseudomonas-like bacteria detection

• Investigating the Prediction of the Pathogenicity of p. Pro۱۴۶Arg Missense Mutation (rs۱۷۷۱۸۸۸۳) in the PD-L۱ Gene with a Bioinformatics Aproach

• In-Silico pathogenicity prediction of rs۸۸۶۰۴۵۸۶۲ and rs۱۴۴۷۸۸۲۵۴ in the LAMB۳ gene in Junctional epidermolysis bullosa (JEB)

• Deciphering the molecular interaction between lysozyme and two commonly utilized pesticides: a comprehensive in-silico and spectroscopic study

• CDK۱ as a Hub Gene: Promising Biomarker for Bladder Cancer Diagnosis

• Design of guide RNAs for genome editing of Yarrowia lipolytica using deep learning

• Evaluating the Induction of Apoptosis via Caspase ۳ Activation: A Comparative Study of Mefenamic Acid and Aspirin